Research Themes

CIVAP Research Themes and Timelines

CIVAP will operate under 4 themes:

  • Regenerative Medicine
  • Oncology
  • Inflammation and Autoimmunity
  • Infectious Diseases

Examples of research projects and objectives are shown below. The themes will become operations in a phased manner: Phase I (Regenerative Medicine) is already in operation. Phase II (Oncology) will commence in July 2017, with Phases III and IV following in 2018 and 2019.

CIVAP is a core facility accessible to all research groups on the Cambridge biomedical campus, as well as to external academic and commercial collaborators. Its objective is to enable research groups to conduct high quality and pioneering in vivo studies rapidly, optimally and cost-effectively, with a particular emphasis on Replacement, Reduction and Refinements in experimental animal use.

CIVAP Services and Facilities

CIVAP will offer the following facilities and services to academic and commercial users:

Regulatory approval to allow in vivo assessment of efficacy, safety and immunogenicity of a range of cellular, biological and pharmacological therapies
Maintenance of common immunodeficient mouse strains in a central facility for shared used
Expertise for generation and maintenance of immune-reconstituted ‘humanised’ mouse models
Expertise for generation of disease models (e.g., diabetes, hepatocellular failure and autoimmunity)
Access to trained technicians with expertise for performing common in vivo procedures (including transplantation into a range of sites)
Expertise and resources for development of new animal and surgical models, procedures and techniques
Unrivalled access to source human tissue through the Cambridge Biorepository for Regenerative Medicine (CBTM) for generation of: humanised mice; regenerative cellular therapies; cellular immunotherapies and tumour models.

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